Antares Pharma Announces Positive Top Line Results From Its Pivotal Phase 3 Study of Anturol Gel for the Treatment of Overactive Bladder
Business Wire, July 27, 2010
– Company on Target to File NDA in 2010 -
EWING, N.J. — Antares Pharma, Inc. (NYSE Amex:AIS) announced today positive results
from its Phase 3 study of AnturolTM Gel in patients with
overactive bladder (OAB). The study met its primary endpoint of a
statistically significant reduction in urinary incontinence episodes for
both doses studied (56 mg daily or 84 mg daily, p=0.028 and 0.033
respectively). An Open Label Extension study, evaluating long term
safety remains ongoing and is scheduled to complete by Q4 2010.
The Phase 3 trial conducted under a Special Protocol Assessment (SPA)
with FDA was a double blind, randomized, parallel placebo-controlled
multi-center study and evaluated the efficacy and safety of Anturol in
600 patients with overactive bladder. The primary objective of the study
was to demonstrate that daily treatment of an 84mg or 56mg dose of
oxybutynin applied in the ATDTM Gel technology for 12 weeks
was superior to placebo for the relief of OAB symptoms.
Paul. K. Wotton Ph.D., President and Chief Executive Officer of Antares
said This success represents another key accomplishment in 2010 and
continues to demonstrate our strong development capabilities. Anturol is
one of many value drivers in our advancing pipeline of development
products. We are delighted with the positive outcome of this Phase 3
trial, as both doses demonstrated a statistically significant reduction
in the primary endpoint of urinary incontinence events as well as a low
incidence of reported side effects. We are on track to file a new drug
application (NDA) with the FDA in 2010.
Roger R. Dmochowski M.D., FACS, Professor, Vanderbilt University,
Department of Urologic Surgery stated Anturol potentially offers many
advantages for the treatment of OAB. Anturol is dispensed in a patient
friendly metered dose pump which provides convenient dosing options.
Both doses tested in the Phase 3 trial demonstrated a low incidence of
side effects and the data also show that Anturol effectively reduces
urinary incontinence episodes within seven days of beginning treatment
compared to placebo.
Secondary end points included changes from baseline in average daily
urinary frequency, void volume, patient perceptions, as well as safety
and tolerability including skin irritation
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These hosts do have monthly bandwidth
These hosts do have monthly bandwidth limits, but the limits are quite high, and most web sites will never reach them. However, if your web site features hundreds of file downloads and gets decent traffic you may be shocked at how soon you’ll reach those bandwidth limits. When you do, your site may be temporarily shut down or you’ll have to pay bandwidth overage charges, which can get pricey. Overall though, mid-range web hosts will be satisfactory for 90% of the web sites out there, and generally offer excellent uptime/reliability. In fact, many web-based businesses are successfully run using a mid-range web host. However, as mentioned previously, web sites that offer large files for download or sites that get a huge amount of traffic may find that a mid-range host doesn’t quite suit their needs. These types of web sites may require “high-end” web hosting solutions, the next topic in our discussion.
High-end web hosts typically service web sites that are extremely popular, have a high amount of traffic, and/or require pretty much 100% uptime.
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Price of escaping to country increases
Price of escaping to country increases
0 Comments | Scunthorpe Evening Telegraph, Jul 23, 2010 | by NIGEL LEWIS
The value of English prime country house prices rose by 2.5 per cent in the second quarter of this year, says a report from agent Knight Frank.
Prices for country retreats have now increased over the past four quarters and are 7.9 per cent higher than they were a year ago. The average value of a prime country house in England is now Pounds 1.4 million. By property type, manor houses performed best in Q2 with a 3.2 per cent rise to Pounds 2.7 million.
The value of cottages rose by 2.4 per cent to Pounds 470,000 and farmhouse values were up 1.9 per cent to an average of Pounds 1.2 million.
The number of rental properties available nationally is continuing to reduce, says the Association Of Residential Lettings Agents (ARLA). Three-quarters of its members say there are more tenants than available properties.
This is an increase from 59 per cent last quarter and 24 per cent in September last year The situation is particularly bad in the south-east, where 76 per cent of member offices report more tenants than properties, says Ian Potter, operations manager of ARLA.
It’s hard to
It’s hard to predict whether all the excess oil producing glands and bacteria have been taken care of. So, you might have to go through the procedure a couple of times till you are able to achieve the desired result.
* The other problem is that this treatment is expensive. The cost ranges depending on the experience of the provider, quality of the laser facilities etc. So, bear in mind that this might not be a one-time deal when you are shopping for laser treatment providers.
So, there you have it. Both sides of the story. While it is easy to measure the drawbacks in monetary terms, it is hard to measure how much the self-esteem of the individual is raised once this procedure is completed successfully. That feeling is one word – priceless!
On http://www.stopping-acne-now.com/ you can read about acne laser treatment & acne scar treatment..
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Golfing cheat tees off jail sentence for benefit fraud
Golfing cheat tees off jail sentence for benefit fraud
0 Comments | Western Morning News, The, Jul 23, 2010
A golf-playing benefits cheat who said he was too disabled to work has been sent to prison for conning the state out of more than Pounds 36,000.
Philip Bond, 62, of Tor Park Road, Torquay, made fraudulent claims for housing, disability, council tax and income support over a 12-year period.
But Exeter Crown Court was told yesterday the only handicap he had was a “respectable” 14-stroke one he built up on the fairways of Dainton Park Golf Club in Ipplepen.
Investigators from the Department for Work and Pensions filmed Bond swinging clubs with apparent ease despite claiming he was so disabled he could barely put on his socks in the morning.
He was told by Judge Stephen Wildblood QC that his deception was “fraudulent, repeated and knowing” from the outset, and was sent to prison for seven months.
Bond admitted 10 counts of dishonestly claiming benefit amounting to Pounds 36,400 between May 1996 and July 2008.
The court was told the main part of the claim, amounting to Pounds 34,360, was for disability living allowance, which Bond began claiming in 1996.
Prosecutor James Cranfield said Bond knew his claim was fraudulent from the outset but that did not stop him making other claims during the period for income support, severe disablement allowance, housing benefit and council tax benefit.
Tax investigators were tipped off that Bond was not only playing twice a week at Dainton Park but also working as a painter and decorator in 2007 and 2008 at the Highweek Inn in Newton Abbot.
He had been a paid-up member of the golf club since 1993, had a “mid-level” handicap and took part in competitions.
Mitigating, Martin Salloway said Bond did have a medical condition known as ankylosing spondylitis which affected the spine. He said Bond’s doctors had recommended he took exercise and he found playing golf the most effective way to do this.
Bond admitted he had lied to the benefits office by exaggerating his symptoms of stiffness and breathlessness. He “felt a sense of grievance” that he was being told he couldn’t claim the benefits he wanted, he said.
Judge Wildblood said: “Each time you received benefit you must have known what you were doing was wrong and that knowledge must have been at the front of your mind over the 12 years you were committing this offence.”
Bond admitted three counts of dishonestly falsifying documents, three of dishonestly failing to notify the Department for Work and Pensions about changes to his circumstances, and further charges of obtaining money, benefits and property by deception.
Since major changes in both physical
Since major changes in both physical inactivity and food explain the development of the obesity and diabetes crisis, rational measures to address both issues are needed. The epidemic of obesity and diabetes has developed in spite of decades of national and local efforts to emphasize the value of `balanced diets’ and to stress the importance of moderate daily exercise. Health education should, therefore, also be designed to support other measures. These include:
? Providing children with a wide variety of physical activities.
? Appropriate urban environments that encourage healthy lifestyle habits for all.
? Teaching healthy eating habits and providing nutritious foods in schools
? Monitoring the weight of children.
? Food labelling.
? Smaller portion sizes.
? Lower prices for healthy foods.
It is important to establish strong national systems and partnerships that enable governments, civil society, and the private sector to evaluate and implement effective new policies.
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It-girl’s jewel identity
It-girl’s jewel identity
0 Comments | Mail on Sunday (London, England), The, July 25, 2010
Once a flaky socialite, Nicole Richie has established herself as a credible designer over the past few years, enjoying enormous success with her Winter Kate clothing line and House of Harlow jewellery. The latter, which is stocked at The Design Centre in the Powerscourt Townhouse Centre in Dublin, is inspired by the 1960s and ’70s and contains stunning gold-plated and textured cuffs, pendants and oversized rings.
Amanda Byram (right) chose an elegant gold pendant from the jewellery line to wear with her one-shouldered dress. For something a little more bling, try this Mawi purse pendant (right), [euro]275, from House of Fraser.
Most of theses companies offer flexible hours,
Most of theses companies offer flexible hours, and usually require between a twelve and forty hour workweek. Some even offer benefits. Other companies consider you an independent business owner or contractor.
When considering a telephone customer service job, you should have a separate phone line for business purposes, a headset phone and possibly a high-speed internet connection (depending on the company, some require this).
There are two basic types of phone customer service positions: inbound and outbound. If you have an inbound position, you are waiting for calls to be transferred to you by the company that are initiated by the customer. In outbound service, you are given a list of customers to call.
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Kids catch on quickly especially when
Kids catch on quickly especially when the teacher starts killing/taking their main players. Stress helps them learn.
5. Emphasize the power of each player. Example: “The queen is very powerful. She can go anywhere, in any direction and sweep across the board, but only the Knight can jump over others. The pawn is a poor peasant/farmer, a foot soldier. He is fed poorly, can’t move quickly, has little of no armour, poor weapons, no horse and is easily killed.
6. I show kids my own main strategy, which is to move a pawn and get the queen out quickly across the board (with the bishops) and to attack, attach, attack. Kids soon see that this often works well.
7. I show the kids that chess can be played solo, by changing seats, or by turning the board around (no ESL learning in this, however), and with an internet partner (little ESL value).
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For example, the yoga exercises like Sun
For example, the yoga exercises like Sun Salutation, Cobra pose, Locust pose, Bow pose, Standing Forward Bend and Kapalabhati few to name are strictly not recommended if somebody is diagnosed with hernia as these exercises may make the hernia problem worse? said Subodh Gupta, the Yoga expert based in London.
Considering the fact that over half a million hernia operations were performed in the United States last year and more than 2 percent of British people are affected by hernia, the question to ask is if all yoga practitioners are aware of their health condition and precautions before beginning the Yoga exercise. Madonna, the famous singer who practices Ashtanga yoga regularly recently had an operation for hernia ( Ashtanga yoga exercise series is a system developed by Mysore based famous Indian Yoga guru Shri K Pattabhi Jois ).
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